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Background: In the US, among non-subsp. enterica serovars, both serovar IIIa 18:z4,z23:- and IIIa 41:z4,z23:- are most frequently linked to human illness, with each serovar contributing to 10–20 cases annually.

NCBI PD link for serovar IIIa 41:z4,z23:-: https://www.ncbi.nlm.nih.gov/pathogens/isolates/#(taxgroup_name:%22Salmonella%20enterica%22)%20AND%20computed_types:(%22serotype=IIIa%2041:z4,z23:-%22)

Genetic characteristics: Serovar IIIa 41:z4,z23:- is highly polyphyletic, with five lineages identified. 

Animal reservoir: Unknown; however, based on host information from the NCBI PD metadata, serovar IIIa 41:z4,z23:- has primarily been isolated from dogs and wild animals, such as snakes and birds (Pelecanus erythrorhynchos). Additionally, two isolates were collected from chicken (n=1) and turkey (n=1), respectively.

Geographical distribution: Serovar IIIa 41:z4,z23:- has been reported in the US, Canada, and Europe including Germany, Ireland, and the UK.  

Human outbreaks: Not clear, at least no recent human outbreaks linked to this serovar have been reported. 

Border rejections: There have been no recent border rejections linked to this serovar. 

Recalls: There have been no recent recalls linked to this serovar. 

Relevant links:

  1. https://stacks.cdc.gov/view/cdc/152398/cdc_152398_DS1.pdf
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC8208698/#R19
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