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Phylogenetic and pan-genomic analyses that included two of the sequenced S. Heidelberg strains and other Salmonella serovars concluded that S. Heidelberg (i) belongs to clade A, according to den Bakker et al. (2011) classification, (ii) appears to have a single evolutionary origin, and (iii) contains 74 gene families unique to this serovar.  

Animal reservoir:Poultry, including chickens and turkeys, are the main reservoirs for serovar Heidelberg. It has also been found in other animals such as cattle, swine, and dogs.

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