For some chemists (mostly theoretical chemists), they benefit from systems are up 24x7. For those who don't, save huge amounts using the cloud by paying only for the resources you actually use.

If there are acceptable down times, bring things down and don't pay for the resources.  There are lots of configurations you can play with to make sure that you have the resources ready when you need them.  This includes configuring your system to spawn additional resources when utilization is high and taking resources away when utilization is low or completely shutting down all resources when the service is not being used. CIT has been using Docker to containerize applications, you can read about it here:

CIT's experience with this service, "The big win is this allows us to easily and quickly build applications from the OS all the way up the stack.  It also allows us to easily move containers or images to different cloud providers if that is of interest."

Some staff in CIT are familiar with the services in Amazon and how to save money by utilizing automation and services.