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Panel

http://purl.org/commons/record/ncbi_gene/24866
denotes an Entrez Gene record "without commitment as to representation" - that is, the record's declarative content independent of whether the record is rendered as XML, ASN, or RDF. The information in the record may change over time as annotations are added and corrections are made, but it will always be about the same "gene" (a term that unfortunately is not defined).
http://purl.org/commons/xml/ncbi_gene/24866
denotes the XML version of the record.
http://purl.org/commons/html/ncbi_gene/24866
denotes a web page presenting information from the record in human-readable form.

Layering

Registering a domain name, directing it to purl.org (CNAME), and basing identifiers on the registered name
From URI-based Naming Systems for Science

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http://purl.obofoundry.org/obo/OBI_0000225 = http://purl.org/obo/OBI_0000225; both reference http://ashby.csail.mit.edu/cgi-bin/obiterm?ref=OBI_0000225

Jon: This might be a way for a collection to continue its own branding when publishing otherwise meaningless persistent identifiers, as when publishing http://hdl.ecommons.cornell.edu/1813/734 instead of http://hdl.handle.net/1813/734 to resolve to http://ecommons.cornell.edu/handle/1813/734