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Genetic characteristics: Salmonella Senftenberg is a polyphyletic serovar, consisting of two lineages and two singleton isolates that do not cluster with any other Salmonella Senftenberg isolateisolates. Although antimicrobial resistance is not widespread in in Salmonella Senftenberg, an extended-spectrum, ß-lactamase strain was linked to infections of patients in a hospital in India. Multidrug resistant (MDR) isolates have also been isolated from production animals in the USA (resistant to multiple drugs, including extended-spectrum cephalosporin). Carriage of the pESI-like megaplasmid, which is associated with Salmonella Infantis, has been linked to these MDR isolates. It has been suggested that Salmonella Seftenberg isolates may be more heat-resistant when compared to other Salmonella serovars.

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