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Background: Salmonella enterica subsp. enterica serovar Worthington (antigenic formula 1,13,23:z:l,w) is a serovar of the O:13 (G) serogroup. Serovar Worthington were was first isolated in 1937 from a young turkey and a chick by Dr. Pomeroy. The name of Worthington came from serovar was named after Worthington, Minnesota, where a the location of the hatchery that the poult of this isolate was purchasedraised the birds carrying the original isolates. Serovar Worthington is was the 2nd 2^nd most common nontyphoidal nontyphoidal Salmonella serovar isolated from human infections in India during 2001-2005.  

The most common source of serovar Worthington is turkey, turkey ceca, and its production environment. This serovar has been reported in in milk powder contamination, vegetables, and seafood. However, serovar Worthington has been frequently reported to cause infection especially in neonatal cases and the pediatric wardwards. Serovar Worthington tends to cause infection in vulnerable groups such as newborns or elderly. Although the symptoms caused by serovar Worthington infection are likely non-typhoidal infection symptoms such as diarrhea or vomiting, in some cases, it can develop to meningitis leading to fatalitydeath. In In 1955, there was a report on serovar Worthington suspected causing gastroenteritis including vomiting from artificial feeding in several newborn babies in a small maternity ward at in an Indonesian hospital. The Another outbreak to involving newborn babies occurred in the ward also occurred in a hospital in Hong Kong in August 1974 leading to 1 from 13 cases died , including 1 death due to meningitis but ; at the time, the outbreak cause source was unable to not identified. However, the second outbreak occurred in five weeks after with infected five newborns and this time revealed Five weeks later, five newborns were infected with the same serovar, and in this instance it was found that the outbreak was caused by the contamination in the tubing system of a suction apparatus, which was used for baby's oropharyngeal suction. The outbreak causing by the same contamination also happened Another outbreak in Pakistan in early 1990s. early 1990s was also linked to contamination of newborn oropharyngeal suction apparatus; Salmonella Worthington was recovered from 18 babies who received suction. Recently, serovar Worthington likely becomes has been found to be multidrug-resistant bacteria , challenging for the treatment especially in neonates and elderly. 

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Genetic characteristics: Serovar Worthington has been found to be polyphyletic with 1 lineage and 1 stand-alone singleton. Salmonella Worthington isolates from preharvest turkey production sources pose both virulence and persistence by carrying virulence genes which are , such as invA, aceK, and sopB, together along with resistance to many antibiotics (tetracycline, erythromycin, bacitracin, novobiocin, and rifampin). Salmonella Worthington has been reported on its ability either acquire as having acquired the third-generation cephalosporin resistance plasmid (bla_DHA-1-carrying IncFII plasmid) from Citrobacter amalonaticus or transfer its own resistance genes consisting of extended-spectrum cephalosporins, monobactam, and fluoroquinolone to Escherichia coli. 

Animal reservoir: Serovar Worthington has been commonly found in turkeys including their environments.

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