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Genetic characteristics: Parkhill et al. sequenced the complete genome (4,809,037 bp) of Salmonella Typhi (CT18) and found this isolate exhibited substantial genetic decay with over 200 pseudogenes, including homologs of key Salmonella Typhimurium virulence genes (e.g., sopE2 and fliB), potentially explaining its human-restricted host specificity. This isolate carries two plasmids: a 218,150 bp multidrug-resistant IncHI1 plasmid (pHCM1) and a 106,516 bp cryptic plasmid (pHCM2) phylogenetically linked to a virulence plasmid of Yersinia pestis. Additionally, it harbors up to 15 Salmonella pathogenicity islands (SPIs 1–7, 9, 11–13, and 15–18).Comparative  Comparative genomics and phylogenetic analyses have shown that S. that serovar Typhi (i) had a monophyletic origin (ii) emerged approx. 30,000 to 50,000 years ago (iiiii) belongs belonged to clade A, according to den Bakker et al. (2011) classification, and (iiiiv) has had 349 gene families unique to this serovar.

Animal reservoir: Salmonella Typhi is a human-restricted serovar.

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