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NCBI PD link for serovar Paratyphi A: https://www.ncbi.nlm.nih.gov/pathogens/isolates/#(taxgroup_name:%22Salmonella%20enterica%22)%20AND%20computed_types:(%22serotype=Paratyphi%20A%22)

Genetic characteristics:Paratyphi A isolates have been found to be resistant to flouroquinolones. A few isolates have been shown to be resistant to azithromycin. Tanmoy et al. developed a genotyping tool, Paratype, based on single nucleotide polymorphisms (SNPs), which classifies Salmonella Paratyphi A into three main clades, nine sub-clades, and 18 genotypes. Each genotype is identified by a unique allele marker situated on an essential gene. Pereira-Dias et al. included a total of 117 serovar Paratyphi A isolates collected from an outbreak of enteric fever in Vadodara, India in their study, with the majority (72.6%) belonging to genotype 2.4.2, the predominant genotype worldwide. The remaining isolates were primarily genotype 2.3 (25.6%), while only two were identified as genotype 2.4.1. All outbreak isolates carried a single gyrA mutation linked to reduced fluoroquinolone susceptibility—74.35% had an S83F substitution, and the rest had an S83Y substitution. Rahman et al. studied serovar Paratyphi A isolated from enteric fever patients in Bangladesh from 2008 to 2018

Animal reservoir: Serovar Paratyphi A is host-restricted to humans.

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  8. https://www.nature.com/articles/s41467-022-35587-6
  9. https://pmc.ncbi.nlm.nih.gov/articles/PMC9973848


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