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Genetic characteristics: A MDR strain of serovar Oslo isolated from urine and stool specimens was reported by McCarthy et al. Kumar et al. found that three out of eight isolates from tropical seafood in India were resistant to carbenicillin, while the remaining five were pan-susceptible. A US study identified one serovar Oslo isolate resistant to trimethoprim/sulfamethoxazole, sulfisoxazole, ampicillin, tetracycline, and chloramphenicol, which possessed a class 1 integron with a gene cassette array of dfrA1.

Jazeela et al. characterized an auxotrophic mutant of serovar Oslo and revealed that the mutant strain demonstrated greater invasion potential compared to the wild-type, although its replication rate was slower in both cell lines. Like the wild-type, the mutant retained cytotoxic activity in in vitro assays. Additionally, infection with the mutant strain led to increased expression of proinflammatory cytokines (TNF-α, IL-1β) and reduced levels of anti-inflammatory cytokines (TGF-β, IL-6, IL-10) in the infected cell lines. Their further analysis found downregulation of most virulence genes from Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) in the mutant under in vitro conditions, except for invA, which remained active in HeLa cells. Their findings suggested that the auxotrophic mutant exhibits favorable characteristics for potential antitumor applications, particularly due to its ability to upregulate tumor-inhibiting cytokine genes in in vitro studies.

Animal reservoir: Unknown, serovar Oslo was previously isolated from seafood and monkey.

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¹ Salmonella Oslo and Korovi were found.

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