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Background: Salmonella enterica subsp. enterica serovar Agona (antigenic formula 1,4,[5],12:f,g,s:[1,2]) is a serovar of the O:4 (B) serogroup. This serovar was first isolated from cattle in Ghana in 1952. Serovar Agona is the 10th most common nontyphoidal Salmonella serotype isolated from human infections in China and is also among the top 20 most frequently reported Salmonella serotypes in the United States.

NCBI PD link for serovar Agona: https://www.ncbi.nlm.nih.gov/pathogens/isolates/#(taxgroup_name:%22Salmonella%20enterica%22)%20AND%20computed_types:(%22serotype=Agona%22)

Genetic characteristics: Whole genome sequences for 74 strains of S. Agona have been deposited at GenBank as of October, 2013. Genomic characteristics of the sequenced S. Agona include (i) a genome size ranging from 4.70 to 4.95 Mb, (ii) a mol G+C% of approx. 52, and (iii) 4,658 to 4,934 predicted genes. Comparative  Comparative genomics of 73 of the sequenced strains identified three lineages of S. serovar Agona that emerged approx. 80 90 years ago.  S. Agona has Serovar Agona has an accessory genome of approx. 1.3 Mb; this accessory genome includes (i) multiple prophages (P2-like, Fels-like, Lambda-like), (ii) antibiotic resistance plasmids (e.g., IncI1 plasmids), (iii) genomic islands, (iv) transposons, and (v) chromosomal integrons.Phylogenetic  Phylogenetic and pan-genomic analyses that included one of the sequenced S. Agona serovar Agona strains and other Salmonella serovars concluded that S. serovar Agona belongs to clade A, according to den Bakker et al. (2011) classification and it contains 133 gene families unique to this serovar.  

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