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Use the "shrinking" service at the end of the work-flow to maximize the amount of shrinking possible. That is, do it after you have the final cropped, at the desired resolution.
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Still "to do"
: Chemistry still has that big job of "image management" and curation which still needs to "sit" somewhere (and it is much larger and broader than the "Chemistry web site", per se). Anyway, whoever will be doing this will have a much easier job now that we've identified these tools.