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The equation for minor loss coefficients for a submerged orifice shown above is used to find the orifice diameter needed.
 
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 A pipe size/macro-mixing combination can be used for a range of flow-rates.  An increase in flow-rates will give that result in a higher head loss for the macro-mixing orifice a significant head loss.   This can actually result in the macro-mixing orifice having a higher head loss than the micro-mixing orifice.  Due to this, the user can select a constraint value for head loss(usually 2 to 10 cm) that will cap how high the macro-mixing head loss can be.  This is done by selecting a larger pipe size and larger macro-mixing orifice.  In figure 2, the results for head loss through the macro-mixer are shown below.  At high flow-rates, macro-mixing head loss becomes higher than micro-mixing head loss. 

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